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Recombinant Infectious bronchitis viruses: potential for a new generation of vaccines

Researchers at The Pirbright Institute and The Roslin Institute have published work investigate the role of the infectious bronchitis virus (IBV) spike (S) protein in generating protection through vaccination. Current vaccine regimes, based on a single serotype, often do not produce sufficient immunity against other serotypes, so two or more different vaccines have to be […]

Two PPRV vaccines protect against all strains

Scientists at The Pirbright Institute have conducted a study to directly compare the ability of two vaccines to protect susceptible animals against wildtype viruses from any of the four genetic lineages of Peste-des-petits-ruminants virus (PPRV). Through analysing the immune response of goats that were administered the vaccines, they were able to demonstrate that both vaccines […]

FMDV contagion in carrier cattle

Foot-and-mouth disease virus (FMDV) is believed to be one of the most contagious pathogens of animals in its acute form; however, there is still controversy over whether it is transmissible from asymptomatic, long-term carriers. Despite the lack of evidence for transmission by direct contact with FMDV carrier cattle, there is demonstrable contagion associated with these […]

Detection of FMDV in milk samples: potential for disease surveillance

Researchers at The Pirbright Institute and the USDA Animal and Plant Health Inspection Service (APHIS) Foreign Animal Disease Diagnostic Laboratory have shown it could be possible to detect Foot-and-mouth disease virus (FMDV) in pooled milk samples stored in bulk tanks. The results suggest that milk testing could contribute to disease surveillance both during and after […]

Research aims to lower the cost of IBV vaccine production

Infectious bronchitis virus (IBV) vaccines are currently produced in hen’s eggs – a cumbersome and expensive process – because most IBV strains do not grow in cell cultures. In a step towards making vaccine production more efficient and reducing costs, a team led by Dr Erica Bickerton at The Pirbright Institute identified the exact genetic […]

Consortium to tackle African swine fever and lumpy skin disease

An international partnership of organisations is working together to control the growing African swine fever (ASF) and lumpy skin disease (LSD) epidemics in Europe and neighbouring countries. The need for a collaborative approach to tackle ASF and LSD has been recognised by the European Union Horizon 2020 programme, which has awarded €5.6 million in funding […]

Method developed to detect FMDV in the environment

Sampling the environment is an effective way to detect Foot-and-mouth disease virus (FMDV), according to a paper published in Applied and Environmental Microbiology. The sampling method, swabbing environmental surfaces where livestock are kept, can be easily performed and can detect viral genetic material that can persist in the environment well beyond the time when livestock […]

Recombinant viral vector for poultry vaccination

Researchers at The Pirbright Institute have developed a new recombinant viral vector-based vaccine that is effective against both Marek’s disease (MD) and infectious bursal disease (IBD). Their study is published in npj Vaccines. Many poultry vaccines currently use a modified herpesvirus of turkeys (HVT) to induce protection. Although these vaccines are effective when used alone, […]

Local immune response to Influenza studied in pigs

Researchers from The Pirbright Institute, University of Bristol, Cardiff University and University of Oxford have developed tools to show how CD8 (killer) T cells in pigs are recruited in large numbers in the lung after infection with influenza or aerosol vaccination. The tools can also be used to identify virus proteins that are recognised by […]

Porcine deltacoronavirus: potential for cross-species transmission?

Researchers have found that Porcine deltacoronavirus (PDCoV) efficiently infects cultured cells of other species, including humans and chickens. The discovery raises concerns about the potential for cross-species transmission. Researchers at The Ohio State University and Utrecht University collaborated to better understand the new virus and its potential reach. Their findings are published in PNAS. Porcine […]