Tag: vaccine development
ASFV vaccine candidate produced in a continuous cell line
The U.S. Department of Agriculture’s Agricultural Research Service (ARS) has announced that an African swine fever virus (ASFV) vaccine candidate has been adapted to grow in a cell line, which means that those involved in vaccine production will no longer have to rely on live pigs and their fresh cells for vaccine production. “This opens […]
Infectious bronchitis virus: increasing vaccine heat resilience could improve performance
Studies from The Pirbright Institute and the University of Edinburgh’s Roslin Institute show that two vaccines against specific strains of infectious bronchitis virus (IBV) do not offer complete protection against a third strain, and that this may be partly down to the temperature range the vaccine virus can survive in. Commercial IBV vaccines are currently […]
IBDV VP4 protein dampens poultry immune response
Work carried out by scientists at The Pirbright Institute has revealed that differences in virulence between strains of Infectious bursal disease virus (IBDV) may be partly down to changes in the VP4 protein. Their findings, published in Frontiers in Cellular and Infection Microbiology, may help explain why very virulent (vv) strains cause high mortality rates […]
Virally vectored ASFV antigens protect pigs from developing severe disease
Researchers at The Pirbright Institute have developed a vectored vaccine, which uses a non-harmful virus (adenovirus prime and modified vaccinia Ankara boost) to deliver eight strategically selected genes from the African swine fever virus (ASFV) genome into pig cells. Once inside the cell, the genes produce viral proteins which primes the pig immune cells to […]
Genetic engineering speeds up poultry vaccine development
Scientists at The Pirbright Institute have used genetic engineering to develop a vaccine that protects birds against both Marek’s disease and avian influenza. They say the process is faster and more efficient compared to previous methods, which will allow poultry vaccine producers to rapidly update vaccine strains in order to keep up with virus evolution. […]
Modified BCG vaccine is compatible with a novel DIVA skin test
Scientists at the University of Surrey have developed a novel vaccine and complementary skin test to protect cattle against bovine tuberculosis. Publishing their findings in Scientific Reports, the researchers reveal they have created a vaccine that is compatible with a synthetic form of the tuberculin skin test (PPD). The BCG vaccine, which is currently used […]
Rift Valley fever vaccine found to be safe in pregnant animals
Researchers have shown that a simian adenovirus vectored vaccine, ChAdOx1 RVF, is effective at protecting pregnant sheep and goats from Rift Valley fever (RVF). They report their findings in npj Vaccines. Infection of livestock with Rift Valley fever virus (RVFV) results in high mortality and poor outcomes during pregnancy, including stillbirths, fetal malformations and abortions. […]
Study of chicken gut cells may aid vaccine design
The colony-stimulating factor 1 receptor (CSF1R) has been shown to be expressed in the follicle-associated epithelium cells in the avian gut-associated lymphoid tissue. This was an unexpected finding as CSF1R is typically expressed in macrophages, not in epithelial cells. The results in studies with chicken cells pave the way for research looking to enhance the […]
Model predicts effectiveness of livestock vaccines
Scientists at The Roslin Institute have developed an epidemiological model to investigate the effectiveness of vaccines for preventing, mitigating or eliminating infectious diseases in livestock. When appropriately applied, even imperfect vaccines can prevent, eliminate or largely reduce the prevalence of viruses, the model shows. The goal of effective vaccination is not only to protect individuals […]
Identification of African swine fever virus antigens for vaccine development
Scientists at The Pirbright Institute have identified African swine fever virus (ASFV) proteins that can induce cellular and humoral immune responses in pigs. Published in Frontiers in Immunology, the study shows that when some pigs were challenged with a virulent strain of ASFV after receiving a vaccine that included the identified proteins, the level of […]