“Global Strategic Alliances for the Coordination of Research on the Major Infectious Diseases of Animals and Zoonoses”

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NEWS

Unique structure of ASFV enzyme may allow drug development

A DNA-copying protein from African swine fever virus (ASFV) has a unique structure that may offer a target for drugs, according to a study published in PLoS Biology by Yiqing Chen and colleagues at Fudan University in Shanghai, China. Viral replication depends in part on a polymerase enzyme, AsfvPolX, that repairs breaks in the DNA, but the structure of this enzyme has not been determined in detail. The authors used X-ray diffraction and nuclear magnetic resonance to solve the structure at atomic resolution. The team found that the enzyme contained a unique binding pocket for the building blocks of DNA (nucleotides), not seen in related enzymes in other organisms. They also found several other unique structural features, including a pair of hydrophobic amino acids that interact with incoming [...]

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Gene editing for PRRSV resistance in pigs

Precision engineering renders target cells of PRRSV resistant to infection with the virus. Researchers have used advanced genetic techniques to produce pigs that are potentially resilient to Porcine reproductive and respiratory syndrome (PRRS). Early tests have revealed that cells from the pigs are completely resistant to infection with both major subtypes of the virus that causes the disease. The animals are otherwise healthy and the change – introduced using gene editing technology – should not affect their ability to fight off other infections, the researchers say. Studies have shown that the PRRS virus targets macrophages. A molecule on the surface of these cells called CD163 plays a key role in enabling the PRRS virus to establish an infection. The research team at the University of Edinburgh’s Roslin Institute, [...]

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Call for Interest on Designation as FAO Reference Centre for Antimicrobial Resistance (AMR)

Members of the Food and Agriculture Organization (FAO) committed at the 39th Session of the FAO Conference (June 2015) to work on the issue of Antimicrobial Resistance (AMR) through Resolution 4/2015. The resolution calls upon both FAO members and the organization itself to address the threat posed by AMR to public health, agriculture production and food safety and security. The FAO Resolution on AMR highlights the support of the food and agriculture sector to implement the Global Action Plan (GAP) on AMR which was developed by the World Health Organization in collaboration with FAO and the World Organisation for Animal Health. In 2016, the FAO Action Plan on Antimicrobial Resistance 2016 – 2020 was developed and published outlining the role of FAO on implementing the GAP. Four focus [...]

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Transmission dynamics of zoonotic tuberculosis in Morocco

A mathematical model of tuberculosis transmission from cattle to humans has been used to estimate the disease cost and simulate potential interventions in Moroccan cattle. In many developing countries, a significant fraction of the tuberculosis burden comes potentially from the tuberculosis bacteria carried by animals, essentially cattle. Efforts to reduce the tuberculosis burden, therefore, must include strategies to reduce incidence of the bacteria in animals using a “One Health” approach. Researchers reporting in PLoS Neglected Tropical Diseases have used a disease modelling approach to analyse the cost and effectiveness of interventions aimed at bovine tuberculosis among cattle in Morocco. Around 18 percent of cattle in Morocco carry Mycobacterim bovis, which can be transmitted to humans through consumption of raw milk or from contact with infected animals. One previous [...]

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EVENTS

17th Indian Veterinary Congress & XXIV Annual Conference of IAAVR

17th Indian Veterinary Congress & XXIV Annual Conference of Indian Association for the Advancement of Veterinary Research (IAAVR) & National Symposium “New Generation Vaccines, Diagnostics for Improvement of Animal & Poultry Health & Productivity vis-à-vis Genomic Interventions for the Societal Benefit.” [Rescheduled]. Contact: Dr. Rishendra Verma Email: rishendra_verma@yahoo.com http://iaavr.org/

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Global Research Alliance on Agricultural Greenhouse Gases, Livestock Research Group

http://globalresearchalliance.org/updates/ Contact:   secretariat@globalresearchalliance.org

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Vaccinology in Africa Master’s Level Course

The 2017 ‘Vaccinology in Africa’ Master’s Level Course is open to applications from students, researchers and professionals resident in East Africa. The course covers the main aspects of human and veterinary vaccinology, the vaccine development process, biomanufacturing, clinical trials, regulatory and ethical issues, highlighting human and veterinary links and synergies from scientific, technological and regulatory perspectives. The course is jointly organised by the host institution, MUII-Plus (Makerere University-UVRI Centre of Excellence for Infection & Immunity Research and Training) in Entebbe, Uganda, and the Jenner Institute, University of Oxford. Participation is competitive and places are allocated based on individual applications. 20 places are available for local residents of Uganda which will cover course fees, travel within Uganda, accommodation and meals during the course. A further 20 bursaries are available [...]

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8th International Conference on Emerging Zoonoses

8th International Conference on Emerging Zoonoses with an emphasis on Emerging and Transboundary Infectious Diseases, which will take place in Manhattan, Kansas, May 7 – 10, 2017. There is a significantly raised awareness that zoonoses and transboundary diseases threaten both human and animal health. Therefore, research and policy should focus on a “One Health” perspective in local, national, and international environments. To properly address these issues, the conference plans to have special workshops which will be organized by experts in their fields. Potential topics might include:  the ecology of emerging zoonotic and transboundary diseases; the role of wildlife in emerging zoonoses and transboundary diseases; cross-species transmission of zoonotic and transboundary pathogens; emerging and neglected influenza viruses; hemorrhagic fever viruses; emerging and transboundary bacterial diseases; outbreak responses to zoonotic [...]

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American Academy of Veterinary Pharmacology and Therapeutics (AAVPT) 2oth Biennial Symposium

The theme for this year’s AAVPT biennial meeting is “The Role of Veterinary Pharmacology in One Health.” It explore the multifaceted challenges faced as veterinary pharmacologists seek to meet the therapeutic needs associated with veterinary species while engaging in efforts to better understand the commonality in physiology, pharmacokinetics, and disease targets that define our One World Health. www.aavpt.org/page/20Biennial

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IX Conferencia Anual Vet+i

IX Conferencia Anual de la Fundación Vet+i-Plataforma Tecnológica Española de Sanidad Animal “Los beneficios para la sociedad de la I+D+i en Sanidad Animal” http://www.vetmasi.es/vetmasi-conferencia-anual/eventos/ix-conferencia-anual-vet+i_3633_15_3749_0_1_in.html Contact: secretaria@vetmasi.es

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