Roadmap for the development of candidate vaccines for liver fluke
Download Liver-Fluke-Vaccine-Roadmap-111
Vector
Dependencies
Next steps
- 7 Vectored vaccines
- 7A Safety
- 7B Delivery route
- 7C Delivery platform
- 7D Efficacy in challenge model
Research Question
What are we trying to achieve and why? What is the problem we are trying to solve?
Using a replicating organism to express the protective antigens generating a stronger longer-lasting immune response
Research Gaps and Challenges
What are the scientific and technological challenges (knowledge gaps needing to be addressed)?
Immune response against the vector
Solution Routes
What approaches could/should be taken to address the research question?
Explore a range of possible vectors – large viruses (Herpes viruses, endogenous retroviruses), protozoa (Trypanosoma theileri, Eimeria), bacteria (replication deficient such as aroA mutants)
Dependencies
What else needs to be done before we can solve this need?
- Identity of the protective antigens
- Successful antigen expression
State Of the Art
Existing knowledge including successes and failures
No specific trials with Fasciola antigens as yet.
Projects
What activities are planned or underway?
Improving the performance of forage legumes through the use of optimal symbiotic partners using the example of sainfoin (Onobrychis viciifolia)
Planned Completion date 31/12/2023
Denmark
Development of a web application for the risk assessment of the worm load of free-range laying hens (Wurmfrei)
Planned Completion date 31/12/2026
Denmark