Projects
In Vivo Evaluation of Avirulent Live B. Bronchiseptica Vaccine to Reduce PRDC Severity
Objectives & Deliverables
Objective:
In vivo assessment of an avirulent live Bordetella bronchiseptica vaccine for ability to reduce disease and/or macroscopic/microscopic lesions associated with porcine respiratory disease complex, specifically disease/lesions following B. bronciseptica coinfection with porcine reproductive and respiratory syndrome virus (PRRSV) or influenza A virus (IAV).
Challenges
Approach:
The Cooperator will provide the vaccine. ARS will obtain sows to farrow at the NADC. Some sows will be given B. bronchiseptica to allow for natural transmission to piglets. Piglets will divided by litter and whole litters will be vaccinated or left unvaccinated with B. bronchiseptica vaccine. At weaning, piglets will be exposed to PRRSV or IAV or remain unexposed. B. bronchiseptica colonization, viral shedding, and lung pathology will be evaluated to assess vaccine efficacy.
Principle Investigator(s)
Planned Completion date: 31/01/2025
United States