Mycoplasmas including CBPP/CCPP roadmap:
Vaccines
Research roadmap for contagious bovine pleuropneumonia (CBPP) vaccine development
Download CBPP vaccine development roadmap final15
Host responses to natural infection
Dependencies
- 17 Host pathogen interactions
- 17A Entry
- 17B Replication
- 17C Persistence/ clearance
Next steps
- 8 Attenuated organisms
- 12 Identity of protective antigens
- 16 Identity of mechanisms of protection
- 16A Antibody response
- 16B Cell mediated immunity
Host responses to natural infection
Research Question
- Identify innate and acquired immune responses to Mmm infection as these should help in understanding mechanisms that lead to disease and immunity.
Research Gaps and Challenges
- The immune response to experimental infection differs significantly when challenged by different routes such as intubation or by contact.
Solution Routes
- Develop in vitro and in vivo options for evaluating host responses to infection.
Dependencies
- A better understanding of host responses and host-pathogen interactions.
State Of the Art
- Several genomics approaches are being used to map this process.
Projects
What activities are planned or underway?
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject A (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject B (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark