Helminths (including anthelmintic resistance) roadmap:
Vaccines
Roadmap for nematode vaccine development
Download Nematode Vaccine Roadmap16
Identity of mechanisms of protection
Identity of mechanisms of protection
Research Question
- Understanding gene expression in both host & parasite over course of infection
- Identify differences between immune responses induced by protective versus non-protective vaccines (e.g. protective native vs. non-protective recombinant vaccine or protective vs. non-protective adjuvant).
- What are the roles of the various antibody classes and cellular responses? Does driving a Th-2 type response benefit the parasite?
Research Gaps and Challenges
- Multiple parasite species in natural infections, different timings & seasonality, possibly different mechanisms of protection, different sites within the host, possibly interacting with other species/co-infections etc.
Solution Routes
- Study the response of “resistant” and “resilient” animals compared to those that are highly susceptible.
- Role of molecular pattern recognition (interaction with TLRs) in determining the immune response.
- Cell types involved in the various stages of infection, including Th1/Th2 balance.
Dependencies
- A better understanding of host-parasite interactions.
State Of the Art
- In general, Th-2 type responses are generated against GI nematodes
Projects
What activities are planned or underway?
Single-nucleotide polymorphisms in the beta-tubulin gene and its relationship with treatment response to albendazole in human soil-transmitted helminths in Southern Mozambique
Planned Completion date 14/09/2022
Source Countries:
Netherlands
An integrated set of novel approaches to counter the emergence and proliferation of invasive and virulent soil-borne nematodes – Project part: Fostering nematode suppression in soils by cover crops and addition of biological antagonists in Organic Farming (NEM-EMERGE)
Planned Completion date 31/12/2027
Source Countries:
Denmark