Helminths (including anthelmintic resistance) roadmap:
Vaccines
Roadmap for nematode vaccine development
Download Nematode Vaccine Roadmap16
Identity of mechanisms of protection
Identity of mechanisms of protection
Research Question
- Understanding gene expression in both host & parasite over course of infection
- Identify differences between immune responses induced by protective versus non-protective vaccines (e.g. protective native vs. non-protective recombinant vaccine or protective vs. non-protective adjuvant).
- What are the roles of the various antibody classes and cellular responses? Does driving a Th-2 type response benefit the parasite?
Research Gaps and Challenges
- Multiple parasite species in natural infections, different timings & seasonality, possibly different mechanisms of protection, different sites within the host, possibly interacting with other species/co-infections etc.
Solution Routes
- Study the response of “resistant” and “resilient” animals compared to those that are highly susceptible.
- Role of molecular pattern recognition (interaction with TLRs) in determining the immune response.
- Cell types involved in the various stages of infection, including Th1/Th2 balance.
Dependencies
- A better understanding of host-parasite interactions.
State Of the Art
- In general, Th-2 type responses are generated against GI nematodes
Projects
What activities are planned or underway?
Improving the performance of forage legumes through the use of optimal symbiotic partners using the example of sainfoin (Onobrychis viciifolia)
Planned Completion date 31/12/2023
Source Countries:
Denmark
Development of a web application for the risk assessment of the worm load of free-range laying hens (Wurmfrei)
Planned Completion date 31/12/2026
Source Countries:
Denmark