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Mycoplasmas including CBPP/CCPP roadmap:
Vaccines

Research roadmap for contagious bovine pleuropneumonia (CBPP) vaccine development

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13

Identity of virulence factors

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Dependencies

Next steps

Identity of virulence factors

Research Question

  1. Identify Mmm factors that contribute to virulence and pathology resulting in disease.
  2. Deletion of virulence factors could result in attenuated Mmm
  3. Antigenic virulence factors are candidate vaccine antigens.

Research Gaps and Challenges

  1. Lack of assays to measure virulence factors.

Solution Routes

  1. Computational approaches to identify candidate genes.
  2. Develop assays to measure virulence.
  3. Map immunity/pathology enhancing antigens.

Dependencies

  1. Standardized cattle breed specific laboratory challenge models that reproduce CBPP caused by natural infection or are acceptable surrogates.
  2. Develop or re-purpose in vitro models that may identify putative virulence factors.

State Of the Art

  1. Precision cut lung slices and cell culture experiments have been used to characterize Mmm by comparing to other mycoplasmas.
  2. Some in vitro assays, e.g., measurement of hydrogen peroxide exist.

Projects

What activities are planned or underway?

Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject B (SURE)

Planned Completion date 31/05/2024

Source Countries:

DenmarkIconDenmark

Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject A (SURE)

Planned Completion date 31/05/2024

Source Countries:

DenmarkIconDenmark