Coronaviruses roadmap:
Control Strategies
Roadmap for the development of disease control strategies for coronaviruses
Download 202410 Draft Coronavirus Disease control research roadmap Final14
Pathogen genome
Pathogen genome
Research Question
- Understanding which genome changes increase pathogenicity and cross-species jump
Research Gaps and Challenges
- Little is known on pathogenesis of bat viruses
- Unknown genomic changes that can increase pathogenicity and cross-species jump
Solution Routes
- Identify genomic targets that are highly conserved and specific to the pathogenic strains
- Reverse genetic studies in-vivo and in vitro infection assays
Dependencies
- Facilitating data sharing and interoperability
- Surveillance strategies
- New technologies for multiplex detection and sequencing strategies
- Continued improvement of whole genome sequencing. technologies (e.g. high-throughput sequencing technologies) for genomic surveillance
Projects
What activities are planned or underway?
Potassium molybdate blocks APN-dependent coronavirus entry by degrading receptor via PIK3C3-mediated autophagy
Planned Completion date 31/01/2025
Source Countries:
Netherlands
Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation
Planned Completion date 28/02/2023
Source Countries:
Europe