Helminths (including anthelmintic resistance) roadmap:
Vaccines
Roadmap for nematode vaccine development
Download Nematode Vaccine Roadmap11
Vector
Dependencies
Next steps
- 7 Vectored vaccines
- 7A Safety
- 7B Delivery route
- 7C Delivery platform
- 7D Efficacy in challenge model
Vector identification for vectored vaccine
Research Question
Using a replicating organism to express the protective antigens for the various parasite species, thereby generating a stronger longer-lasting immune response
Research Gaps and Challenges
- Detrimental immune response against the vector.
- Vector delivering appropriate antigens in optimal configuration to trigger protective immune response.
Solution Routes
- Explore a range of possible vectors – large viruses (Herpes viruses, endogenous retroviruses), protozoa (Trypanosoma Theileria, Eimeria), bacteria (replication deficient, such as aroA mutants
Dependencies
- Identity of relevant protective antigens.
- Understanding the protective mechanism for the respective parasite species.
- Understanding dynamics of polyvalent protective immune responses to avoid unintended consequences
Projects
What activities are planned or underway?
Single-nucleotide polymorphisms in the beta-tubulin gene and its relationship with treatment response to albendazole in human soil-transmitted helminths in Southern Mozambique
Planned Completion date 14/09/2022
Source Countries:
Netherlands
An integrated set of novel approaches to counter the emergence and proliferation of invasive and virulent soil-borne nematodes – Project part: Fostering nematode suppression in soils by cover crops and addition of biological antagonists in Organic Farming (NEM-EMERGE)
Planned Completion date 31/12/2027
Source Countries:
Denmark