Helminths (including anthelmintic resistance) roadmap:
Vaccines
Roadmap for nematode vaccine development
Download Nematode Vaccine Roadmap11
Vector
Dependencies
Next steps
- 7 Vectored vaccines
- 7A Safety
- 7B Delivery route
- 7C Delivery platform
- 7D Efficacy in challenge model
Vector identification for vectored vaccine
Research Question
Using a replicating organism to express the protective antigens for the various parasite species, thereby generating a stronger longer-lasting immune response
Research Gaps and Challenges
- Detrimental immune response against the vector.
- Vector delivering appropriate antigens in optimal configuration to trigger protective immune response.
Solution Routes
- Explore a range of possible vectors – large viruses (Herpes viruses, endogenous retroviruses), protozoa (Trypanosoma Theileria, Eimeria), bacteria (replication deficient, such as aroA mutants
Dependencies
- Identity of relevant protective antigens.
- Understanding the protective mechanism for the respective parasite species.
- Understanding dynamics of polyvalent protective immune responses to avoid unintended consequences
Projects
What activities are planned or underway?
Improving the performance of forage legumes through the use of optimal symbiotic partners using the example of sainfoin (Onobrychis viciifolia)
Planned Completion date 31/12/2023
Source Countries:
Denmark
Development of a web application for the risk assessment of the worm load of free-range laying hens (Wurmfrei)
Planned Completion date 31/12/2026
Source Countries:
Denmark