Tag: bovine tuberculosis

Resilience to bovine TB traced to key genes

Researchers have mapped active and inactive genes in bovine alveolar macrophages (bAM), which play a key role in countering bovine tuberculosis (bTB) infections. The findings of the study, led by scientists at University College Dublin (UCD) in collaboration with The Roslin Institute, are published in Frontiers in Genetics. In order to map which genes in […]

TB or not TB? The fight for immunity. Inaugural lecture of Professor Jayne Hope. The Roslin Institute, Easter Bush Campus, Edinburgh

This inaugural lecture will discuss work carried out by Professor Hope starting with her PhD studies of the immune response to chemical allergens in mice. This led to a career-long interest in dendritic cells and innate immunity that is now being applied to studies of vaccines for tuberculosis in cows. The lecture will discuss differences […]

Modified BCG vaccine is compatible with a novel DIVA skin test

Scientists at the University of Surrey have developed a novel vaccine and complementary skin test to protect cattle against bovine tuberculosis. Publishing their findings in Scientific Reports, the researchers reveal they have created a vaccine that is compatible with a synthetic form of the tuberculin skin test (PPD). The BCG vaccine, which is currently used […]

African buffalo provide insights into the genetics of tuberculosis resistance

Morris Animal Foundation-funded researchers at Oregon State University discovered areas in the African buffalo (Syncerus caffer) genome linked to risk for tuberculosis (TB) infection. The researchers discovered areas of genetic code variation near genes associated with immunity to bacterial infections and demonstrated that these variations correlated with TB resistance. The team published their findings in […]

Badger culling increases ranging behaviour among survivors

A study led by researchers from the Zoological Society of London (ZSL) and Imperial College London has found that culling drives badgers to roam further afield. They say this helps to explain why the practice, intended to reduce bovine tuberculosis (TB) transmission, can sometimes exacerbate the problem instead. Published in the Journal of Applied Ecology, […]

Tuberculosis test differentiates infected from vaccinated animals

Skin tests that can distinguish between cattle that are infected with tuberculosis (TB) and those that have been vaccinated against the disease have been created by an international team of scientists. The findings of the study are published in Science Advances. The traditional TB tuberculin skin test shows a positive result for cattle that have […]

Lactic acid bacteria from badgers display inhibitory activity to BCG

The use of the human tuberculosis vaccine, Bacillus Calmette-Guerin (BCG), in badgers has been suggested as a humane and long-term solution to reduce tuberculosis transmission from badgers to cattle. However, experimental studies show variable protection. Among the possibilities for this variation is that the resident gut bacteria may influence the success of oral vaccination in […]

Cost and scale of field trials for bovine TB vaccine may make them unfeasible

Field trials for a vaccine to protect cattle against bovine tuberculosis (bovine TB) would need to involve 500 herds – potentially as many as 75,000-100,000 cattle – to demonstrate cost effectiveness for farmers, concludes a study published in eLife. Instead, the researchers suggest that the scale and cost of estimating the effect of a vaccine […]

Characterization of Mycobacterium bovis in Mozambique

The most extensive study to date of the genetic diversity of Mycobacterium bovis isolates from Mozambique is reported in PLOS Neglected Tropical Diseases. Bovine tuberculosis (BTB) is of global concern for multiple reasons – the economic impact on animal production, the potential spread to wildlife, and the risk of transmission to humans. While BTB is […]

Roadmap to combat bovine and zoonotic tuberculosis

The Roadmap for Zoonotic Tuberculosis was launched at the 48th Union World Conference on Lung Health, which took place in Guadalajara, Mexico, 11-14 October 2017. Four partners in health, the World Health Organization (WHO), the World Organisation for Animal Health (OIE), the Food and Agriculture Organization of the United Nations (FAO) and the International Union […]