Tag: Marek’s disease virus
Variation in chicken interferon genes may account for susceptibility/resistance to viral pathogens
A study of different lines of chickens, known to be either more resistant or more susceptible to common poultry viruses, has uncovered dozens of variations in genes with a central role in the chicken immune response to infection. The findings, published in Animal Genetics, may point to genetic variations that determine birds’ response to infection, […]
Marek’s disease virus hijacks the cholesterol pathways of poultry cells to replicate
A study by scientists from The Pirbright Institute has confirmed that cholesterol production and transport play a crucial role in how Marek’s disease virus (MDV) infects poultry cells. Researchers also found that inhibiting a protein involved in this pathway can reduce virus replication and spread between cells. Researchers in Pirbright’s Avian Immunology Group took an […]
Marek’s disease: new gene editing technique aids vaccine development.
New approach offers a simple and efficient method to manipulate the Turkey herpesvirus genome for rapid development of recombinant vaccines. Scientists at The Pirbright Institute have used genetic engineering to develop a more efficient and effective vaccine for Marek’s disease, which could pave the way for a new generation of poultry disease vaccines. Marek’s disease virus (MDV) […]