Tag: pigs

Genetically modified pigs resist infection with Classical swine fever virus

Researchers have developed genetically modified pigs that are protected from Classical swine fever virus (CSFV), according to a study published in PLOS Pathogens by Hongsheng Ouyang of Jilin University, and colleagues. Ouyang and colleagues generated CSFV-resistant pigs by combining the gene-editing tool CRISPR/Cas9 with RNA interference (RNAi), a technique that silences gene expression. The researchers […]

Animal movements have played a critical role in the spread of MRSA in Danish pigs

Pig movements have facilitated the spread of a few MRSA lineages highly adapted to the selection pressures exerted by antimicrobial use in pigs In a study published in mBio, Danish and U.S. researchers have shown that the rapid spread of livestock-associated methicillin-resistant Staphylococcus aureus clonal complex 398 (LA-MRSA CC398) is due to the expansion of […]

Gene-edited pigs are resistant to TGEV

A team of researchers from the University of Missouri, Kansas State University and Genus plc has succeeded in producing pigs that are resistant to Transmissible gastroenteritis virus (TGEV) by means of gene editing. Their study is published in Transgenic Research. “Previous research had identified an enzyme called ANPEP as a potential receptor for the virus, […]

Local immune response to Influenza studied in pigs

Researchers from The Pirbright Institute, University of Bristol, Cardiff University and University of Oxford have developed tools to show how CD8 (killer) T cells in pigs are recruited in large numbers in the lung after infection with influenza or aerosol vaccination. The tools can also be used to identify virus proteins that are recognised by […]

Gene editing for PRRSV resistance in pigs

Precision engineering renders target cells of PRRSV resistant to infection with the virus. Researchers have used advanced genetic techniques to produce pigs that are potentially resilient to Porcine reproductive and respiratory syndrome (PRRS). Early tests have revealed that cells from the pigs are completely resistant to infection with both major subtypes of the virus that […]