Roadmap for the development of candidate vaccines for FMD

What are we trying to achieve and why? What is the problem we are trying to solve?

To generate knowledge on virus replication

What are the scientific and technological challenges (knowledge gaps needing to be addressed)?

• Investigate virus replication at the point of entrance in animals (how to prevent replication at the primary sites)
• Investigate the mechanisms that lead to the formation of vesicles and how the infection carries on

What approaches could/should be taken to address the research question?

What else needs to be done before we can solve this need?

Existing knowledge including successes and failures