Influenza roadmap:
Diagnostic Tests
Roadmap for the development of diagnostic test for influenza
Download Influenza-diagnostic-development-roadmap7
Host-pathogen interaction
Dependencies
Next steps
Host-pathogen interaction
Research Question
- Identify the most appropriate target for diagnosis based on the Host pathogen interaction
Research Gaps and Challenges
- Lack of knowledge on the impact of the host’s infection status on the (immune) response
- Virus-host interactions control species-specific pathology.
- Virus-specific host susceptibility, including carrier state.
Solution Routes
- Need to better understand the relevant mechanisms for an effective immune response, role of cross-reactivity and cell-mediated immunity
- Need to understand resistance or susceptibility factors (e.g. intracellular enzymes in different organs, endosomal pH, adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), tumor necrosis factor (TNF) etc.) towards HPAI viruses in different wild (main reservoirs) and domestic bird and mammal species
- Role of microRNAs in modulating pathogenesis
- Host responses for diagnosis of infections, for clues about viral pathogenesis
Dependencies
- Challenge studies that provide foundational information
- Longitudinal studies
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Automated non-invasive Detection of Surface Contamination and Optimizing Surface Biofilm Removal Conditions in Large-Scale Food Processing Equipment
Planned Completion date 31/08/2028
Source Countries:
United States