Influenza roadmap:
Diagnostic Tests
Roadmap for the development of diagnostic test for influenza
Download Influenza-diagnostic-development-roadmap9
Organism detection
Organism detection
Research Question
- Detection of influenza viruses in various species and matrices including environmental sources
Research Gaps and Challenges
- Sensitivity of detection versus specificity versus contamination risks
- Cost effectiveness, commercialization
- How many/much samples are needed to determine prevalence/risk?
- I.e.: pools, environmental samples, versus direct from animal
Solution Routes
- Sampling methods and transport for low resource settings
- Assessment of local need to reach acceptable confirmatory diagnosis
- Implementation of routine targeted testing for endemic IAVs that can be scaled up during an outbreak and/or serve as background data when a new IAV strain emerges or is a concern
- Validate and verify novel solutions (field PCR, LAMP, etc) for in-field and laboratory methods
- Standardize diagnostics from environmental samples
- Surveillance sensitivity should be decided
- Protocols to work through co-infections in order to capture all pathogens
- Rapid sensitive and specific methods for field detection (subtype specific if possible?)
Dependencies
- Clear country requirements for diagnostic (matrices and species)
- Defining diagnostic needs according to region, poultry vs wild birds vs livestock vs humans etc
- Understanding IAV ecology for a location/system in order to target surveillance
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Automated non-invasive Detection of Surface Contamination and Optimizing Surface Biofilm Removal Conditions in Large-Scale Food Processing Equipment
Planned Completion date 31/08/2028
Source Countries:
United States