Influenza roadmap:
Diagnostic Tests
Roadmap for the development of diagnostic test for influenza
Download Influenza-diagnostic-development-roadmapB
Genetic
Genetic
Research Question
- Rapid, cost-effective tools for
– genetic detection
– Sequence analysis and characterization
– Sequence reporting/databases that communicate with each other (I.e., sequences from one database can be downloaded and analyzed in another without loss of integrity)
Research Gaps and Challenges
- Systematic approaches for analyzing and reporting viral genome sequences
- Issues around samples most relevant for infection in different species with swabs alone not necessarily enabling detection
- Approaches that are specific i.e. need to know what you have before you can test
Solution Routes
- Effective deployment of 3rd -gen sequencing technologies for both wet and dry-lab protocols, allowing point-of-incidence analysis
- Rapid characterization of variants circulating in the field via high throughput point-of-care technology
- Improve sensitivity and purification methods for whole-genome sequencing
- Evaluation of whole genome sequencing platforms
- Develop highly multiplexed PCR assays
- Improved and easily employed metagenomic pipelines
- Commercialization or Increased availability of novel technology like viability PCR tests
Dependencies
- Training of more bio informaticists to mine and interpret the data
- Understand the relationship between genetic detection and transmission IRL
- Improved reference databases/faster assignment of genetic clades as they appear
- Turnkey solutions to allow use in more veterinary labs
- Reduce complexity of testing procedure to make it more accessible
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Automated non-invasive Detection of Surface Contamination and Optimizing Surface Biofilm Removal Conditions in Large-Scale Food Processing Equipment
Planned Completion date 31/08/2028
Source Countries:
United States