Mycoplasmas including CBPP/CCPP roadmap:
Vaccines
Research roadmap for contagious bovine pleuropneumonia (CBPP) vaccine development
Download CBPP vaccine development roadmap final5
DNA/RNA vaccines
DNA/RNA vaccines
Research Question
- Assess if DNA/RNA platform technologies can be used to develop safer and more efficacious vaccines than current LAVs.
Research Gaps and Challenges
- Lack of in vitro assays to guide immunogenicity and efficacy testing.
- DNA/RNA based antigen delivery systems have not been optimized for use in cattle.
- Regulatory restrictions may limit use of nucleic acid-based vaccines.
- Cost could limit the use of these technologies.
Solution Routes
- Assess DNA and RNA (mRNA and sa-RNA) formulations, route and dose of immunization with a control antigen in small-scale immunogenicity studies in target species.
- Assess ability to meet minimal and desired TPPs.
- Assess ability to scale-up and manufacture.
Dependencies
- Standardize cattle breed specific laboratory challenge models that reproduce CBPP caused by natural infection or are acceptable surrogate models.
- Need optimized methods for antigen delivery via these platforms to prime antibody and T-cell responses.
State Of the Art
- Experimental vaccine antigens have been identified.
Projects
What activities are planned or underway?
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject B (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject A (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark