Mycoplasmas including CBPP/CCPP roadmap:
Vaccines
Research roadmap for contagious bovine pleuropneumonia (CBPP) vaccine development
Download CBPP vaccine development roadmap final9
Adjuvant
Dependencies
Next steps
- 4 Inactivated vaccines
- 4A Safety
- 4B Delivery route
- 4C Delivery platform
- 4D Efficacy in challenge model
- 5 DNA/RNA vaccines
- 5A Safety
- 5B Delivery route
- 5C Delivery platform
- 5D Efficacy in challenge model
- 6 Subunit vaccines
- 6A Safety
- 6B Delivery route
- 6C Delivery platform
- 6D Efficacy in challenge model
Adjuvant
Research Question
- Use adjuvants to generate an optimal immune response to different types of antigen delivery systems in cattle.
Research Gaps and Challenges
- While there are some guidelines on the use of different types of adjuvants, immunogenicity studies are needed.
- Insufficient knowledge on molecular adjuvants to skew immune responses.
- Lack of in vitro assays that correlate/associate with immunity to CBPP.
Solution Routes
- Further studies with Montanide and other adjuvants with the subunit vaccine.
Dependencies
- Standardized cattle breed specific laboratory challenge models that reproduce CBPP caused by natural infection or are acceptable surrogates.
- Identity of protective mechanisms and immune correlates of protection in vitro and in vivo.
- Assess ability to meet minimal and desired TPPs.
- Assess ability to scale-up and manufacture.
State Of the Art
- Experimental vaccine antigens have been identified.
Projects
What activities are planned or underway?
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject A (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject B (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark