Mycoplasmas including CBPP/CCPP roadmap:
Vaccines
Research roadmap for contagious bovine pleuropneumonia (CBPP) vaccine development
Download CBPP vaccine development roadmap final6
Subunit vaccines
Subunit vaccines
Research Question
- Assess if subunit platform technologies can be used to develop safer and more efficacious vaccines than current LAVs.
- Identify and test candidate subunit vaccine antigens.
Research Gaps and Challenges
- Develop a thermotolerant subunit vaccine with DIVA properties.
- Subunit-based vaccines still at the experimental stage.
- Lack of in vitro assays to guide immunogenicity and efficacy testing.
Solution Routes
- Reverse vaccinology approaches to antigen identification are being tested.
- Identify antigens for a DIVA vaccine.
- Assess formulations, route and dose of immunization in small-scale immunogenicity studies.
- Assess ability to meet minimal and desired TPPs.
- Assess ability to scale-up and manufacture.
Dependencies
- Standardized cattle breed specific laboratory challenge models that reproduce CBPP caused by natural infection or are acceptable surrogates.
- Better understanding of immune correlates of protection.
- Assess ability to meet minimal and desired TPPs.
- Assess ability to scale-up and manufacture.
State Of the Art
- A combination of four proteins for an experimental vaccine has been identified. This does not preclude the need for identification of additional antigens.
Projects
What activities are planned or underway?
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject B (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject A (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark