Mycoplasmas including CBPP/CCPP roadmap:
Vaccines
Research roadmap for contagious bovine pleuropneumonia (CBPP) vaccine development
Download CBPP vaccine development roadmap final7
Vectored vaccines
Vectored vaccines
Research Question
- Vectored antigen delivery systems may provoke stronger immune responses and be easier to manufacture and deliver than protein-based vaccines.
Research Gaps and Challenges
- Lack of in vitro assays to guide immunogenicity and efficacy testing.
- Regulatory restrictions for approval of vaccines derived using GMO technology.
- There are many viral vectored systems that could be used.
Solution Routes
- Assess formulations, route and dose of immunization in small-scale immunogenicity studies.
- Assess ability to meet minimal and desired TPPs.
- Assess ability to scale-up and manufacture.
Dependencies
- Identification of Mmm antigens that are targets of protective adaptive and innate immune responses to infection.
- Standardized cattle breed specific laboratory challenge models that reproduce CBPP caused by natural infection or are acceptable surrogates.
State Of the Art
- Experimental vaccine antigens have been identified.
Projects
What activities are planned or underway?
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject A (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark
Collaborative project: Stressless examination for pathogens associated with bovine respiratory disease complex Stressless fUtuRE – subproject B (SURE)
Planned Completion date 31/05/2024
Source Countries:
Denmark