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Helminths (including anthelmintic resistance) roadmap:
Vaccines

Roadmap for nematode vaccine development

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9

Adjuvant

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Dependencies

Next steps

  • 5 DNA/RNA vaccines
  • 5A Safety
  • 5B Delivery route
  • 5C Delivery platform
  • 5D Efficacy in challenge model
  • 6 Subunit vaccine
  • 6A Safety
  • 6B Delivery route
  • 6C Delivery platform
  • 6D Efficacy in challenge model
Conventional and molecular adjuvants

Research Question

  • Attempting to optimise the host’s protective immune response to antigens from a number of parasite species.
  • To identify suitable adjuvants for conventional and nucleic acid-based vaccines, including an effective delivery system.

Research Gaps and Challenges

  • The protective immune response required for the different parasite species may involve different arms of the immune response and different expression/delivery systems.
  • Understanding the mechanism of action of adjuvants
  • Many adjuvants are proprietary i.e. IP still held by commercial companies

Solution Routes

  • Establish the required immune response by using information and data from previous vaccine trials with variable levels of efficacy.
  • Identify adjuvants and administration routes which provoke the desired response.
  • Establish the correct/appropriate immune response using various combinations of antigens and adjuvants.
  • Use of novel adjuvants with PAMPs to stimulate correct responses

Dependencies

  • Precise identity of protective antigens.
  • Improved knowledge of the immune mechanisms associated with vaccine induced protection.
  • Availability of suitable adjuvants to provoke required response in required species.
  • Licensing for use in livestock species/food animals.

State Of the Art

  • QuilA and aluminium hydroxide gave variable results, possibly depending on the parasite species. Some use of bacterial extract/LPS in administration of Hc23, for example

Projects

What activities are planned or underway?

Improving the performance of forage legumes through the use of optimal symbiotic partners using the example of sainfoin (Onobrychis viciifolia)

Planned Completion date 31/12/2023

Source Countries:

DenmarkIconDenmark

Development of a web application for the risk assessment of the worm load of free-range laying hens (Wurmfrei)

Planned Completion date 31/12/2026

Source Countries:

DenmarkIconDenmark