Roadmap for nematode vaccine development

Download Nematode Vaccine Roadmap

DNA/RNA vaccines

visit roadmap

Dependencies

9 Adjuvant

Next steps

1 Vaccine

Development of nucleic acid-based vaccines

Research Question

Attempting to avoid issues (folding/conformation/post-translational modifications) of recombinant protein-based vaccines by using mammalian expression in the parasite’s definitive host

Research Gaps and Challenges

DNA vaccine approach has not worked as well in ruminants as in rodent models
Regulatory issues, especially for use in food animals

Solution Routes

DNA vaccines incorporating sequences of host cytokines to drive the immune response in correct direction
Self-amplifying RNA technology

Dependencies

How acceptable are nucleic acid-based vaccines for livestock i.e. food animals, GM etc.?

State Of the Art

Bi-cistronic DNA vaccine technology incorporating cytokines well established e.g. in poultry vaccines.
Self-replicating/amplifying technology based on alphavirus machinery commercially exploited by e.g. Glaxo and Tiba Biotech.
DNA vaccine technology being used in goats for immunity against Haemonchus (Yan et al 2014)Self-replicating mRNA vaccines have not yet been widely tested for efficacy against multicellular parasites (schistosomes are exception to this – Tiba Biotech have recently presented some data on this at IVVN, London 2019)