Porcine Reproductive & Respiratory Syndrome roadmap:
Vaccines
Roadmap for development of a candidate vaccine for PRRSV
Download PRRSV Vaccine Roadmap9
Adjuvant
Dependencies
- 10 Expression system
- 12 Identity of virulence factors
Next steps
- 4 Inactivated vaccines
- 4A Safety
- 4B Delivery route
- 4C Delivery platform
- 4D Efficacy in challenge model
- 5 DNA/RNA vaccines
- 5A Safety
- 5B Delivery route
- 5C Delivery platform
- 5D Efficacy in challenge model
- 6 Subunit vaccines
- 6A Safety
- 6B Delivery route
- 6C Delivery platform
- 6D Efficacy in challenge model
Identifying suitable delivery systems for subunit and inactivated whole virus vaccine candidates
Research Question
- Generate an optimal immune response to the various vaccine candidates resulting in sterile immunity to wild type virus
Research Gaps and Challenges
- Generating both a strong VN Ab and a CTC response
Solution Routes
- Immune response to antigens delivered on nanoparticles
- Immune response following inclusion of various adjuvants with the candidate vaccines
Dependencies
- Identity of protective antigens
Projects
What activities are planned or underway?
Generating antibodies broadly neutralising porcine reproductive and respiratory syndrome virus (PRRSV)
Planned Completion date 31/12/2025
Source Countries:
Denmark
Identification of interferon stimulated genes that control Toxoplasma in pig macrophages
Planned Completion date 01/03/2026
Source Countries:
United Kingdom