
Roadmap for the development of diagnostic tests for FMD
Download FMD Diagnostic_Lead Summaries_Roadmap updateC
Infectious
Research Question
What are we trying to achieve and why? What is the problem we are trying to solve?
To establish if there are biological markers of persistence and identify them.
Research Gaps and Challenges
What are the scientific and technological challenges
(knowledge gaps needing to be addressed)?
- Identify markers of carrier state
Solution Routes
What approaches could/should be taken to address the research question?
Proteomic approaches in persistent /not persistent cells would allow to detect specific markers of persistence.
Dependencies
What else needs to be done before we can solve this need?
Understand the mechanisms of persistence.
The pathogen and host factors that contribute to FMDV persistence are currently not understood.
State Of the Art
Existing knowledge including successes and failures
Some mechanisms of persistence at the cellular level (in the soft palate) begin to be understood.
Projects
What activities are planned or underway?
An integrated epidemiological and economic analysis of foot and mouth disease (FMD) in Thailand : Evaluation of FMD control measures
Planned Completion date 03/10/2023
Netherlands
Foot-and-mouth disease virus : Structurally unraveling antigenicity for vaccine quality control
Planned Completion date 07/05/2024
Netherlands