Influenza roadmap:
Control Strategies
Roadmap for the development of disease control strategies for influenza
Download Influenza-control-development-roadmapB
Therapeutics
Therapeutics
Research Question
- To develop effective and affordable therapeutics for influenza viruses for targeted species
- Develop strategies for therapeutics use
Research Gaps and Challenges
- Risk of the emergence and spread of resistance
- Identify appropriate uses of antivirals in animal
- Residuals in products and environment (withdrawal time and MRL)
- Cost of therapeutics for animal production systems
- Preservation of therapeutics for human use and possible high value companion animals to reduce antiviral resistance development
- Need to have clear definitions on how to determine when a flock/bird is negative
- Is there a need/market for therapeutics in controlling outbreaks?
Solution Routes
- Development of flu antivirals (particularly for horses and companion animals?)—reduce virus shedding while avoiding spread of drug resistance esp. to human/swine flu
- Demonstrate safety for animal, human and environment of new therapeutics, defining
- Withdrawal period and MRL
- Explore approaches that might overcome resistance issues like siRNA
- Define how to use therapeutics in control: use and depopulate approach or use in animals that don’t enter the food chain: Zoo birds,
endangered species, hi value breeders, etc. - Decision tool or decision matrix to guide practitioners should be made
available - Establish if therapeutics have been implemented/used regionally
Dependencies
- Involve public health side here
State Of the Art
- Currently therapeutics can’t be used in production animals as stamping out is applied for biosafety reasons
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Automated non-invasive Detection of Surface Contamination and Optimizing Surface Biofilm Removal Conditions in Large-Scale Food Processing Equipment
Planned Completion date 31/08/2028
Source Countries:
United States