Influenza roadmap:
Control Strategies
Roadmap for the development of disease control strategies for influenza
Download Influenza-control-development-roadmapB
Therapeutics
Therapeutics
Research Question
- To develop effective and affordable therapeutics for influenza viruses for targeted species
- Develop strategies for therapeutics use
Research Gaps and Challenges
- Risk of the emergence and spread of resistance
- Identify appropriate uses of antivirals in animal
- Residuals in products and environment (withdrawal time and MRL)
- Cost of therapeutics for animal production systems
- Preservation of therapeutics for human use and possible high value companion animals to reduce antiviral resistance development
- Need to have clear definitions on how to determine when a flock/bird is negative
- Is there a need/market for therapeutics in controlling outbreaks?
Solution Routes
- Development of flu antivirals (particularly for horses and companion animals?)—reduce virus shedding while avoiding spread of drug resistance esp. to human/swine flu
- Demonstrate safety for animal, human and environment of new therapeutics, defining
- Withdrawal period and MRL
- Explore approaches that might overcome resistance issues like siRNA
- Define how to use therapeutics in control: use and depopulate approach or use in animals that don’t enter the food chain: Zoo birds,
endangered species, hi value breeders, etc. - Decision tool or decision matrix to guide practitioners should be made
available - Establish if therapeutics have been implemented/used regionally
Dependencies
- Involve public health side here
State Of the Art
- Currently therapeutics can’t be used in production animals as stamping out is applied for biosafety reasons
Projects
What activities are planned or underway?
Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta
Planned Completion date 21/10/2024
Source Countries:
Netherlands
Impact of host age on viral and bacterial communities in a waterbird population.
Planned Completion date 01/11/2022
Source Countries:
Netherlands