Home Bovine Tuberculosis (bTB) [Phage typing] – Phage typing – bTB
Bovine Tuberculosis (bTB) roadmap:
Diagnostic Tests

Roadmap for the development of diagnostic test for bTB

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Phage typing

Phage typing

Research Question

What are we trying to achieve and why? What is the problem we are trying to solve?

Evaluation of phage-based direct M. bovis detection.

Research Gaps and Challenges

What are the scientific and technological challenges
(knowledge gaps needing to be addressed)?

  • Culture time.
  • Detection in biological samples including faeces.
  • Improved culture media.
  • Sample concentration.
  • Performing phage typing requires specialized technical expertise and facilities.
  • Time and labor Intensive.
  • Interpretation and standardization.
  • Limited discriminatory power.

Solution Routes

What approaches could/should be taken to address the research question?

  • Objective evaluation of candidate methods on reference samples.
  • Consider latent class analyses.
  • Follow STARD and QUADAS-2 guidelines for reporting and designing diagnostic accuracy studies.
  • Development of enrichment broth.

Dependencies

What else needs to be done before we can solve this need?

 

State Of the Art

Existing knowledge including successes and failures