Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap5
DNA/RNA
DNA/RNA vaccines
Research Question
- Efficacious and safe nucleic acid-based vaccines
Research Gaps and Challenges
- Durable protection
- Identification of the most suitable antigens and its genetic code.
- Adjuvants for DNA/RNA vaccines
- Storage and delivery of vaccine
- Cost-effectiveness
Solution Routes
- Enhanced immunogenicity using molecular adjuvants
- Production and trial (in-ovo trials) of the most suitable antigens
Dependencies
- Develop adjuvants that can increase immunogenicity
State Of the Art
- There are mRNA candidate vaccines currently under clinical trials. DNA
vaccine licensed in US but not currently in use. RNA vaccine have
limited use in LMIC due to storage issues
Projects
What activities are planned or underway?
US-UK Collab: Avian influenza virus in cattle, a framework for forecasting transmission dynamics of zoonotic disease in livestock systems
Planned Completion date 31/01/2030
Source Countries:
United States
PARTNERSHIP:Harnessing Bovine Organoids to Advance HPAI Influenza A Virus Research
Planned Completion date 14/03/2029
Source Countries:
United States