Influenza roadmap:
Control Strategies
Roadmap for the development of disease control strategies for influenza
Download Influenza-control-development-roadmap13
Host genetics
Host genetics
Research Question
- Improve knowledge of host genetics in relation to susceptibility
Research Gaps and Challenges
- How to manipulate bird genetics and / or anti – viral state responses without vaccine use?
- Any new genetic improvement has a cost on the physiology (e.g. birds will grow more slowly)
- Understanding the genetic behind the host immune systems of resistant animals (e.g. ducks/ostriches)
Solution Routes
- Identify molecular markers of host range in different birds (we know a lot more about what it takes for a virus to transmit from birds to
humans than the same about different bird species) - NGS , variant analysis bioinformatics tools , combined with experimental in vivo studies in different bird species – Host / virus risk
assessment matrix - Study of host genomes for identifying factors contributing to resistance
- Improve the immune responses of hosts to vaccination (turkeys especially)
- Transgenomic studies of infected ostriches/ducks to determine the resistant genes and how they can be bred into poultry
- Evaluate the impact of developing more resistant hosts that will live among humans and wildlife that are still susceptible
- Study immunization capacities of vaccination and genetics modification combined
Dependencies
- Better understanding of avian immunology
- Acceptance of consumers in case of GM
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Alternatives to Antibiotics: Neonatal Immunomodulation to Improve Disease Resistance in Animals
Planned Completion date 31/05/2026
Source Countries:
United States