Influenza roadmap:
Control Strategies
Roadmap for the development of disease control strategies for influenza
Download Influenza-control-development-roadmap9
Host-pathogen-environment interactions
Dependencies
Next steps
Host-pathogen-environment interactions
Research Question
- Improved understanding of the host-pathogen-environmental interactions
Research Gaps and Challenges
- Understanding the mechanisms behind increased pathogenicity observed with some H9N2 and H5N2 LPAI strains
- Clades and strain and subtype differences complicated a single way to address the issues
- Potential role of the vasculature in HPAI pathogenesis
- Consequences for disease ecology in wild bird species of the wide range of avian species susceptibility of H5N1
- Understanding why some duck species are resistant to infection and disease compared to terrestrial poultry
- Are there better ways to cluster groups of viruses that behave similarly to have groups of solution?
- Role of maternal immunity and vaccination in disease transmission
- Role of scavengers (dogs, cats, birds) and carriers like rats in infected
premises
Solution Routes
- Increasing understanding of potential reservoir species at the human/animal interface
- Monitoring of point-of-entry into high-risk areas (introduction of HPAI from Asia/Europe to Nigeria) via migratory waterfowl
- Viral, host, and environmental factors that influence the risk of acquiring an HA multibasic cleavage site
- Transmission experimental models for complex biological systems e.g., live bird markets, ponds where wild birds gather, bird feeders, sow
barns - Quantify the transmission role of scavengers (dogs, cats, birds) and carriers like rats in infected premises
Dependencies
- Standardization of pathogenesis/transmission models and experimental influenza delivery routes
Projects
What activities are planned or underway?
Impact of host age on viral and bacterial communities in a waterbird population.
Planned Completion date 01/11/2022
Source Countries:
Netherlands
Association of biosecurity and hygiene practices with avian influenza A/H5 and A/H9 virus infections in turkey farms.
Planned Completion date 14/03/2024
Source Countries:
Netherlands