Influenza roadmap:
Control Strategies
Roadmap for the development of disease control strategies for influenza
Download Influenza-control-development-roadmapA
Active Infection
Active Infection
Research Question
- Duration (and quantification?) of infectious windows for various subtypes
- Windows of susceptibility (species, physiological status, age, presence of MDAs, etc) and shedding
Research Gaps and Challenges
- Effect of mutations at receptor binding site on viral replication and bird/mammalian species adaptation
- Determinants of viral shedding from respiratory vs. intestinal tracts
- Role of unregulated cytokine expression in production of vaccine associated enhanced respiratory disease of swine (important also for
other different species and virus strains)
Solution Routes
- Comparative studies of pathogenesis with different influenza viruses in the swine host
- Virus shedding patterns at the individual and flock level and age group level
- Replication and transmission efficiency studies: compare similar studies e.g. using Mexican lineage H5N2 LPAIV and / or Asian H9N2
- Studies on the state of active infection in hosts with varying levels of immunity
Dependencies
- Challenge studies with various hosts/ages/immunity/viral strains
Projects
What activities are planned or underway?
Impact of host age on viral and bacterial communities in a waterbird population.
Planned Completion date 01/11/2022
Source Countries:
Netherlands
Association of biosecurity and hygiene practices with avian influenza A/H5 and A/H9 virus infections in turkey farms.
Planned Completion date 14/03/2024
Source Countries:
Netherlands