Influenza roadmap:
Control Strategies
Roadmap for the development of disease control strategies for influenza
Download Influenza-control-development-roadmapA
Active Infection
Active Infection
Research Question
- Duration (and quantification?) of infectious windows for various subtypes
- Windows of susceptibility (species, physiological status, age, presence of MDAs, etc) and shedding
Research Gaps and Challenges
- Effect of mutations at receptor binding site on viral replication and bird/mammalian species adaptation
- Determinants of viral shedding from respiratory vs. intestinal tracts
- Role of unregulated cytokine expression in production of vaccine associated enhanced respiratory disease of swine (important also for
other different species and virus strains)
Solution Routes
- Comparative studies of pathogenesis with different influenza viruses in the swine host
- Virus shedding patterns at the individual and flock level and age group level
- Replication and transmission efficiency studies: compare similar studies e.g. using Mexican lineage H5N2 LPAIV and / or Asian H9N2
- Studies on the state of active infection in hosts with varying levels of immunity
Dependencies
- Challenge studies with various hosts/ages/immunity/viral strains
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Automated non-invasive Detection of Surface Contamination and Optimizing Surface Biofilm Removal Conditions in Large-Scale Food Processing Equipment
Planned Completion date 31/08/2028
Source Countries:
United States