Roadmap for the development of candidate vaccines for FMD

What are we trying to achieve and why? What is the problem we are trying to solve?

To gain an improved understanding of how FMDV enters, replicates and survives in and is released from infected cells.

What are the scientific and technological challenges (knowledge gaps needing to be addressed)?

• Provide a holistic model for challenge model that helps to define tropism
• Explain the mechanisms that govern permissiveness to infection of distinct species- breeds, and how do these factors apply to variability of virulence across cattle breeds
• Determine the mechanisms of emergence of viruses (why some and not others?)

What approaches could/should be taken to address the research question?

Exploitation of precise, quantitative, high-throughput molecular techniques to study FMDV for advancing understanding of pathogenesis at the cellular level

What else needs to be done before we can solve this need?

Genome sequence of various FMDV isolates

Existing knowledge including successes and failures