Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmapC
Persistence/clearance
Persistence/clearance
Research Question
- Identify the factors that influences susceptibility/resistance to infection
Research Gaps and Challenges
- Understand how stress influences virus susceptibility
- Improved understanding of the mechanisms of resistance of some species of fowl and endemic situation in swine
- Levels of immune expression in different species due to virus infection
Solution Routes
- Study the mechanisms of resistance of ducks to HPAIV infection compared to other birds
- Identify the host factors that influences high susceptibility of turkeys to HPAIV
- Genetic determinants of resistance to HPAI strains in known reservoir species (e.g. ducks)
- Mechanism of action of duck RIG-I in conferring AI resistance, and whether there are homologues in other avian species
- Information on a possible carrier state in some species or immune-suppressed individuals
- Understand how some LPAIV subtypes can affect the immune response and subsequent susceptibility/restriction to further infection
- Identification of carrier bird species
- Research on memory T cell immunity against AI, because is present for short period of time (months)
Dependencies
- Existence of carrier state in some species (pheasants) or immunocompromised animals
- Understanding the routes of transmission in different species
- Breeding conditions are extremely important for successful vaccination
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Alternatives to Antibiotics: Neonatal Immunomodulation to Improve Disease Resistance in Animals
Planned Completion date 31/05/2026
Source Countries:
United States