Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmapB
Replication
Replication
Research Question
- Knowledge on mechanisms that increase fitness/adaptability in different host range
Research Gaps and Challenges
- Limited knowledge on the functions of each gene segment in terms of virus-host interactions aiding in the replication and/or increase in
virulence. - Limited knowledge on virus replication markers (e.g. antibodies to NS proteins or other)
Solution Routes
- Identification of viral gene segments or specific amino acid residues that are critical in altering the phenotype of each AIV subtype
(replication fitness and virulence) - Identify virulence determinants other than the cleavage site of HA both for LPAI and also for HPAI viruses capable of promoting replication in specific organic districts.
- Mechanisms behind increased pathology observed with some H9Nx and H5N2 LPAI strains
- ‘Cost’ effective studies related to virus and host fitness
State Of the Art
- In avian Influenza, the hemagglutinin proteolytic cleavage site is known to be the major determinant of virulence of Influenza for gallinaceous birds, however, there is variation among HPAI viruses in the severity of the disease. The viral mechanisms for these differences are unknown
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Automated non-invasive Detection of Surface Contamination and Optimizing Surface Biofilm Removal Conditions in Large-Scale Food Processing Equipment
Planned Completion date 31/08/2028
Source Countries:
United States