Influenza roadmap:
Diagnostic Tests
Roadmap for the development of diagnostic test for influenza
Download Influenza-diagnostic-development-roadmapB
Cell mediated immunity
Cell-mediated immunity
Research Question
- Diagnose the presence and valence of cell-mediated immunity against AIV
Research Gaps and Challenges
- High laboratory specialization and technical skills of staff required
- Limited understanding of variation of mechanisms between species and viral strains
- Need for specific equipment to measure immune cells (I.e.: FACS, etc)
- Variable genetic backgrounds of host (I.e.: commercial breeds versus backyard stocks)
Solution Routes
- Develop technically undemanding and cost-effective tools to define (parts) of CMI
- Role of cell-mediated immunity (CMI) in individual animal recovery and outbreak outcomes
- Tools to define immune cell populations in avian species
- Test to predict cell mediated levels and correlate with vaccine protection
Dependencies
- Basic data on the development of cellular immune effectors in various avian species
- Research facilities that can hold animals for a long period of time (months) to determine if CMI is protective against heterologous challenge
Projects
What activities are planned or underway?
Impact of host age on viral and bacterial communities in a waterbird population.
Planned Completion date 01/11/2022
Source Countries:
Netherlands
Planning for emerging infectious disease pandemics
Planned Completion date 26/07/2021
Source Countries:
Netherlands