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14

Identity of immunomodulators

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Dependencies

Next steps

Identity of immunomodulators

Research Question

To identify how the parasite modulates host immune responses.  If the host could be immunised against these would it result in the parasite being eliminated? How does this translate across multiple parasite species?

Research Gaps and Challenges

  • What does the parasite use in vivo to perform these functions during host-parasite interaction? How does this differ between parasite species, is there any consensus?
  • Downregulation of responses to co-infections?

Solution Routes

  • Establish which parasite genes are being expressed at different life-cycle stages and their role in parasite feeding, establishment, migration etc.

Dependencies

  • An improved understanding of host-parasite interactions.

State Of the Art

  • Area not as well developed in GIN as in trematodes

Projects

What activities are planned or underway?

Single-nucleotide polymorphisms in the beta-tubulin gene and its relationship with treatment response to albendazole in human soil-transmitted helminths in Southern Mozambique

Planned Completion date 14/09/2022

Source Countries:

NetherlandsIconNetherlands

An integrated set of novel approaches to counter the emergence and proliferation of invasive and virulent soil-borne nematodes – Project part: Fostering nematode suppression in soils by cover crops and addition of biological antagonists in Organic Farming (NEM-EMERGE)

Planned Completion date 31/12/2027

Source Countries:

DenmarkIconDenmark