Roadmap for nematode vaccine development

How the host and parasite interact, allowing or inhibiting parasite establishment, feeding and reproduction

• Establishment of the neuroendocrine mechanisms of parasite-induced in-appetance.

• Establish which parasite genes are being expressed at different stages of the life-cycle and their role in parasite feeding, establishment and reproduction.
• Establish the degree of genetic variation in parasite populations and the impact of these variations on the host-parasite interaction and implications for vaccination.

• Good quality accessible annotated parasite genome sequences.
• Model systems for each species and relevant co-infections.
• Reagents to dissect the immune responses (+/- protection)

• Ostertagia/Teladorsagia/Trichuris influence protein digestion and utilisation.
• Adequate knowledge of many systems for single species infections, paucity of studies/data on co-infections (helminths + other pathogens)