Helminths (including anthelmintic resistance) roadmap:
Vaccines
Roadmap for nematode vaccine development
Download Nematode Vaccine Roadmap14
Identity of immunomodulators
Dependencies
- 17 Host-pathogen interactions
- 17A Entry
- 17B Replication
- 17C Persistence/ clearance
Next steps
Identity of immunomodulators
Research Question
To identify how the parasite modulates host immune responses. If the host could be immunised against these would it result in the parasite being eliminated? How does this translate across multiple parasite species?
Research Gaps and Challenges
- What does the parasite use in vivo to perform these functions during host-parasite interaction? How does this differ between parasite species, is there any consensus?
- Downregulation of responses to co-infections?
Solution Routes
- Establish which parasite genes are being expressed at different life-cycle stages and their role in parasite feeding, establishment, migration etc.
Dependencies
- An improved understanding of host-parasite interactions.
State Of the Art
- Area not as well developed in GIN as in trematodes
Projects
What activities are planned or underway?
Improving the performance of forage legumes through the use of optimal symbiotic partners using the example of sainfoin (Onobrychis viciifolia)
Planned Completion date 31/12/2023
Source Countries:
Denmark
Development of a web application for the risk assessment of the worm load of free-range laying hens (Wurmfrei)
Planned Completion date 31/12/2026
Source Countries:
Denmark