Helminths (including anthelmintic resistance) roadmap:
Vaccines
Roadmap for nematode vaccine development
Download Nematode Vaccine Roadmap13
Identity of virulence factors
Dependencies
- 17 Host-pathogen interactions
- 17A Entry
- 17B Replication
- 17C Persistence/ clearance
Next steps
Identity of parasite virulence factors
Research Question
To identify the factors that aid parasite establishment, feeding and survival. If the host could be immunised against these would it result in the parasite being unable to feed or establish?
Research Gaps and Challenges
- What does the parasite use in vivo to perform these functions during host-parasite interaction? How does this differ between parasite species, is there any consensus?
- Downregulation of responses to co-infections?
Solution Routes
- Establish which parasite genes are being expressed at different stages of establishment, feeding and reproduction and their role in parasite virulence
Dependencies
- An improved understanding of host-parasite interactions.
- An in vitro culture system to mimic natural conditions
- A suitable animal model for host-parasite interactions
State Of the Art
Multiple studies to identify immunomodulators, recent niche-specific transcriptomic work (Sci Rep. 2017 Aug 3;7(1):7214.)
Projects
What activities are planned or underway?
Improving the performance of forage legumes through the use of optimal symbiotic partners using the example of sainfoin (Onobrychis viciifolia)
Planned Completion date 31/12/2023
Source Countries:
Denmark
Development of a web application for the risk assessment of the worm load of free-range laying hens (Wurmfrei)
Planned Completion date 31/12/2026
Source Countries:
Denmark