Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmapB
Cell-mediated immunity
Cell-mediated immunity
Research Question
- Identify the role of cellular immune response to protect from infection
Research Gaps and Challenges
- Understand the role (and duration) of the cellular immune response in protection and in the pathogenesis of different influenza strains
- Understanding of the cellular immune response of chickens to HPAI and its significance during infection
Solution Routes
- Role of cell mediated immunity in protection following infection in wild birds versus poultry, and in particular its role in determining transmission
- Characterization of the post-vaccination adaptive cellular immune response in swine
- Passive transfer studies
- Study on LPAI capacity to replicate within birds in extra respiratory and extra GI sites and the relative alteration of immunity response
- Improved diagnostic tools to measure the cellular immune response that allows us to predict protection
Interferon type I and type II needs to be measure - Which phenotype of immune cells respond to infection of vaccines
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Automated non-invasive Detection of Surface Contamination and Optimizing Surface Biofilm Removal Conditions in Large-Scale Food Processing Equipment
Planned Completion date 31/08/2028
Source Countries:
United States