Influenza roadmap:
Control Strategies
Roadmap for the development of disease control strategies for influenza
Download Influenza-control-development-roadmap14
Pathogen genome
Pathogen genome
Research Question
- Understand the influenza genome (pathogenicity, immune suppression, adaptation to new species, ecology, impact of interventions such as vaccination on evolution, etc.)
- What allows LPAIV to switch to HPAIV in H5 and H7 and not in other subtypes
- What makes the AI to change into a strain dangerous for humans
Research Gaps and Challenges
- Reassortment and continuing spread of H5N8 (goose Guandong lineage H5 viruses)
- Rate of genetic change and factors affecting
- Mechanisms of gene reassortment between virus subtypes
Solution Routes
- Continuing development of NGS-based whole genome sequencing
- Effective deployment of 3rd -gen sequencing technologies for both wet- and dry-lab protocols, allowing point-of-incidence analysis
- Maps of virulence signatures for artificial intelligence / machine learning algorithms that can better link genotype to phenotype
- Molecular signatures in viruses associated with improved environmental stability (effect of ammonia , temperature ) and vaccination
- Sequences and metadata from viruses in a broad variety of hosts and under varied conditions
- Sequences from IAV events in which various viral phenotypes are suspected (aerosol transmission, survival in the environment,
multi-species infection, etc.)
Dependencies
- Improved data sharing of sequences – especially in real time
- Mechanisms of intra-host virus evolution
Projects
What activities are planned or underway?
Impact of host age on viral and bacterial communities in a waterbird population.
Planned Completion date 01/11/2022
Source Countries:
Netherlands
Association of biosecurity and hygiene practices with avian influenza A/H5 and A/H9 virus infections in turkey farms.
Planned Completion date 14/03/2024
Source Countries:
Netherlands