Roadmap for the development of candidate vaccine for bTB

What are we trying to achieve and why? What is the problem we are trying to solve?

The development of a novel attenuated vaccine that gives better protection than BCG and allows differentiation of infected and vaccinated animals

What are the scientific and technological challenges
(knowledge gaps needing to be addressed)?

Which strain of the organism to start with Slow growing organisms in culture

What approaches could/should be taken to address the research question?

Establishing the immune responses to genetically modifies M Bovis and BCG
Challenge experiments involving animals vaccinated with candidate organisms.

What else needs to be done before we can solve this need?

The generation of GM organisms where the genes for selected virulence factors have been removed.
The genome sequence of M Bovis strains

Existing knowledge including successes and failures