Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap3
Rationally attenuated candidates
Rationally attenuated candidates
Research Question
- Develop safe live rationally attenuated vaccine candidate
Research Gaps and Challenges
- Safety for VPH- vaccines without risk of reassortment
- Regulatory issues regarding vaccine usage
- No incentive for industry to invest in Al vaccines that can’t be used
Solution Routes
- Mechanisms to reduce shedding (route, type of immune response)
- Cold-adapted LAIVs vaccines?
State Of the Art
US Patent No. 11,214,799 B2 (Jan 4th 2022) entitled ‘HA-specific
influenza virus attenuated vaccine comprising mutations in segment 7
and uses therefor’; D.R. Kapczynski, P. Digard, L. Vervelde and D.
Suarez
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Alternatives to Antibiotics: Neonatal Immunomodulation to Improve Disease Resistance in Animals
Planned Completion date 31/05/2026
Source Countries:
United States