Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap6
Subunit vaccines
Subunit vaccines
Research Question
- Immunogenic subunit vaccines and optimal expression systems
Research Gaps and Challenges
- Low immunogenicity
- Can be developed as multivalent with several mixture of antigens.
- Cost effective
- Still fairly empirical with respect to success of in the antigenic/stability
properties of the antigens - Adjuvants in general (killed vaccines and other vaccine platforms) need
further research
Solution Routes
- Use of adjuvants that could increase immunogenicity
- Production and trial of the most suitable antigens
Dependencies
- Develop adjuvants that could increase immunogenicity
- For commercialization, adjuvant withdrawal time is a major hurdle
depending on species and use
State Of the Art
- Baculous virus
Projects
What activities are planned or underway?
planning for emerging infectious disease pandemics
Planned Completion date 26/07/2021
Source Countries:
Netherlands
Association of biosecurity and hygiene practices with avian influenza A/H5 and A/H9 virus infections in turkey farms.
Planned Completion date 14/03/2024
Source Countries:
Netherlands