Roadmap for the development of candidate vaccines for FMD
Download FMD Vaccine Lead Summaries_Roadmap update13
Identity of virulence factors
Dependencies
Next steps
Research Question
What are we trying to achieve and why? What is the problem we are trying to solve?
Identifying and removal of the factors contributing to pathological changes are essential for generating rationally
attenuated vaccines Identify determinants of viral virulence for different serotypes of FMDV in cattle, sheep, and swine
Research Gaps and Challenges
What are the scientific and technological challenges (knowledge gaps needing to be addressed)?
- Identify genetic determinants of virulence
- Study of virulence determinants observed in the field
- Assess role of subclinical infection
Solution Routes
What approaches could/should be taken to address the research question?
Generation of a range of knock-out viruses and their use in experimental infections to establish the impact of the changes on virulence
Dependencies
What else needs to be done before we can solve this need?
Host-pathogen interaction
State Of the Art
Existing knowledge including successes and failures
New molecules involved in the FMDV life cycle have been identified, some may have a role in virulence such as: RHA,
Sam68, JMJD6, Gemin5, Beclin 1, Vimentin, DCTN3 and LYPLA/ATP1. However, it is still not clear which host factors are critical for virulence.
Projects
What activities are planned or underway?
An integrated epidemiological and economic analysis of foot and mouth disease (FMD) in Thailand : Evaluation of FMD control measures
Planned Completion date 03/10/2023
Netherlands
Foot-and-mouth disease virus : Structurally unraveling antigenicity for vaccine quality control
Planned Completion date 07/05/2024
Netherlands