Projects
Evaluating a Self-Boosting Vaccine Delivery Platform Using Ad5-FMD
Topic: Foot and Mouth Disease
Objectives & Deliverables
Objective:
Previous research on the stability of Adenovirus type 5 (Ad5)-vectored expression systems (i.e., Ad5-Gluciferase) using a specific formulation resulted in stable luminescent signal both in vitro and in vivo. The objective of this collaborative effort is to conduct an in vivo proof-of-concept study to evaluate the efficacy of a self-boosting microneedle formulation using the Ad5-Foot and Mouth Disease (FMD) vectored expression system. Additionally, this study aims to evaluate the immunological efficiency of this novel delivery system.
Challenges
Approach:
1. Fabricating and characterizing the simple version of the Ad5-FMD vaccine microneedle formulation with immediate release, sufficient vaccine dose, mechanical strength and stability in vitro. 2. Characterizing the immunogenic efficiency and safety of the simple version microneedles in vivo.
Principle Investigator(s)
Planned Completion date: 31/07/2026
United States