Projects
IDENTIFICATION OF IMPROVED DIAGNOSTIC MARKERS FOR BRUCELLA SUIS VIA SCREENING WITH A BRUCELLA PAN-PROTEOME MICROARRAY AND ELISA PROTOTYPES FOR USDA
Topic: Brucellosis
Summary
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<b>Animal Health Component</b>
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<b>Research Effort Categories</b><br>
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Objectives & Deliverables
<b>Project Methods</b><br> We will select and testa large set of swine and bovine culture-confirmedB. suispositive samples with a series of brucellosis serologic tests for further characterization. These samples will then be screened on a novel pan-Brucellaproteome microarray consisting of 3,734 full-length or fragmented proteins representing 3,090 unique genes out of which 2,401 are from the core proteome conserved among all Brucella speciesto identify novel diagnostic antigen candidates for the detection ofB. suisinfection. We will further validate the identified biomarker candidates in an ELISA format and will provide ELISA prototypes to USDA for independent validation.
Principle Investigator(s)
Planned Completion date: 31/05/2025
Effort: $642,250.00
Project Status
ACTIVE
Principal Investigator(s)
National Institute of Food and Agriculture
Researcher Organisations
IMMPORT THERAPEUTICS, INC.
United Kingdom