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Diagnostics (tools and technologies) roadmap:
Diagnostic Tests

Roadmap for diagnostic test development

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2

Validation/Proficiency
    "] --> 35041["

    1

    Fit-for-purpose diagnostic tool
      "] 35043["

      3

      Technology optimisation
        "] --> 35042["

        2

        Validation/Proficiency
          "] 35044["

          4

          Stage-specific responses
            "] --> 35043["

            3

            Technology optimisation
              "] 35045["

              5

              Host response"] --> 35044["

              4

              Stage-specific responses
                "] 35045["

                5

                Host response"] --> 35052["

                6

                Biomarkers
                  "] 35052["

                  6

                  Biomarkers
                    "] --> 35043["

                    3

                    Technology optimisation
                      "] 35050["

                      7

                      Host-pathogen interactions"] --> 35045["

                      5

                      Host response"] 35059["

                      8

                      Characterisation
                        "] --> 35043["

                        3

                        Technology optimisation
                          "] 35062["

                          9

                          Organism detection"] --> 35052["

                          6

                          Biomarkers
                            "] 35062["

                            9

                            Organism detection"] --> 35059["

                            8

                            Characterisation
                              "] 35068["

                              10

                              Sample type / transportation / preparation
                                "] --> 35050["

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                                Host-pathogen interactions"] 35068["

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                                Sample type / transportation / preparation
                                  "] --> 35062["

                                  9

                                  Organism detection"] linkStyle default stroke-width:1px,stroke:#3bcaf2
                                  Lead Summary Challenges and gap analysis
                                  1 Fit-for-purpose diagnostic tool Diagnostic
                                  2 Validation/Proficiency Validation
                                  3 Technology optimisation Detection of host responses
                                  4 Stage-specific responses Stage-specific antigens
                                  5B Cell-mediated immunity Cell-mediated immunity
                                  5A AB responses Antibody responses
                                  5 Host response Immune response
                                  6 Biomarkers Biomarkers
                                  7D Immune Immune
                                  7C Infectious Persistence/clearance
                                  7B Exposed Replication
                                  7A Susceptible Entry
                                  7 Host-pathogen interactions Host-pathogen interactions
                                  8 Characterisation Characterisation
                                  9B Genetic Genome detection
                                  9A Direct detection Direct detection/identification
                                  9 Organism detection Organism detection
                                  10 Sample type / transportation / preparation Sample type / transportation / preparation